The Genomic Feature and Variation Ontology (GFVO) is modeled to represent genomic data using the Resource Description Format (RDF) or Linked Data using JSON (JSON-LD). It is captures the contents of data files that adhere to the Generic Feature Format Version 3 (GFF3, http://www.sequenceontology.org/resources/gff3.html), the General Transfer Format (GTF, http://mblab.wustl.edu/GTF22.html), the Genome Variation Format Version 1 (GVF, http://www.sequenceontology.org/resources/gvf.html), and the Variant Call Format (VCF, http://vcftools.sourceforge.net/specs.html), as well as the FASTA format (http://en.wikipedia.org/wiki/FASTA_format). The creation of the ontology was inspired by previous work of Robert Hoehndorf on RDF2OWL (http://code.google.com/p/rdf2owl). NOTE: GFVO in BioPortal is a simplified version without ontology imports and having class/property equivalences removed. The full ontology is available at: http://www.biointerchange.org/gfvo